Is anti-TNF switching in refractory Still’s disease safe and effective?
Identifieur interne : 001549 ( Main/Exploration ); précédent : 001548; suivant : 001550Is anti-TNF switching in refractory Still’s disease safe and effective?
Auteurs : Nadia Emi Aikawa [Brésil] ; Ana Cristina De Medeiros Ribeiro [Brésil] ; Carla Gonçalves Schain Saad [Brésil] ; Rosa Maria Rodrigues Pereira [Brésil] ; Mauricio Levy [Brésil] ; Clovis A. Silva [Brésil] ; Eloísa Bonfá [Brésil] ; Jozélio Freire De Carvalho [Brésil]Source :
- Clinical Rheumatology [ 0770-3198 ] ; 2011-08-01.
English descriptors
- KwdEn :
Abstract
Abstract: Still’s disease (SD) is a rare chronic inflammatory disease characterized by polyarthritis, systemic symptoms, and elevated inflammatory markers. Of note, 74 SD cases were reported with anti-tumoral necrosis factor (TNF) therapy and the experience of switching is limited to five patients. During a 3-year period, SD cases were 1.9% of 319 rheumatic patients that received anti-TNF agents in the infusion center of our University Hospital. In this manuscript, the authors add six new cases of refractory SD who had clinical and laboratory response to TNF blockers and report the outcome of switching in five of them. Partial or complete response was achieved by four of six (66.7%) patients and three of four (75%) required switching. Regarding safety, five of six (83.3%) had adverse events. Anti-TNF treatment with switching seems to be a valid approach for refractory SD patients.
Url:
DOI: 10.1007/s10067-011-1735-0
Affiliations:
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Dr. Arnaldo, no. 455, 3° andar, sala 3190-Cerqueira César, CEP 05403-010, São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Rheumatology</title><title level="j" type="sub">Journal of the International League of Associations for Rheumatology</title><title level="j" type="abbrev">Clin Rheumatol</title><idno type="ISSN">0770-3198</idno><idno type="eISSN">1434-9949</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>London</pubPlace><date type="published" when="2011-08-01">2011-08-01</date><biblScope unit="volume">30</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1129">1129</biblScope><biblScope unit="page" to="1134">1134</biblScope></imprint><idno type="ISSN">0770-3198</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0770-3198</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adalimumab</term><term>Anti-TNF</term><term>Etanercept</term><term>Infliximab</term><term>Still’s disease</term><term>Switching</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Still’s disease (SD) is a rare chronic inflammatory disease characterized by polyarthritis, systemic symptoms, and elevated inflammatory markers. Of note, 74 SD cases were reported with anti-tumoral necrosis factor (TNF) therapy and the experience of switching is limited to five patients. During a 3-year period, SD cases were 1.9% of 319 rheumatic patients that received anti-TNF agents in the infusion center of our University Hospital. In this manuscript, the authors add six new cases of refractory SD who had clinical and laboratory response to TNF blockers and report the outcome of switching in five of them. Partial or complete response was achieved by four of six (66.7%) patients and three of four (75%) required switching. Regarding safety, five of six (83.3%) had adverse events. Anti-TNF treatment with switching seems to be a valid approach for refractory SD patients.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Aikawa, Nadia Emi" sort="Aikawa, Nadia Emi" uniqKey="Aikawa N" first="Nadia Emi" last="Aikawa">Nadia Emi Aikawa</name></region><name sortKey="Aikawa, Nadia Emi" sort="Aikawa, Nadia Emi" uniqKey="Aikawa N" first="Nadia Emi" last="Aikawa">Nadia Emi Aikawa</name><name sortKey="Aikawa, Nadia Emi" sort="Aikawa, Nadia Emi" uniqKey="Aikawa N" first="Nadia Emi" last="Aikawa">Nadia Emi Aikawa</name><name sortKey="Bonfa, Eloisa" sort="Bonfa, Eloisa" uniqKey="Bonfa E" first="Eloísa" last="Bonfá">Eloísa Bonfá</name><name sortKey="Bonfa, Eloisa" sort="Bonfa, Eloisa" uniqKey="Bonfa E" first="Eloísa" last="Bonfá">Eloísa Bonfá</name><name sortKey="De Carvalho, Jozelio Freire" sort="De Carvalho, Jozelio Freire" uniqKey="De Carvalho J" first="Jozélio Freire" last="De Carvalho">Jozélio Freire De Carvalho</name><name sortKey="De Carvalho, Jozelio Freire" sort="De Carvalho, Jozelio Freire" uniqKey="De Carvalho J" first="Jozélio Freire" last="De Carvalho">Jozélio Freire De Carvalho</name><name sortKey="De Carvalho, Jozelio Freire" sort="De Carvalho, Jozelio Freire" uniqKey="De Carvalho J" first="Jozélio Freire" last="De Carvalho">Jozélio Freire De Carvalho</name><name sortKey="De Medeiros Ribeiro, Ana Cristina" sort="De Medeiros Ribeiro, Ana Cristina" uniqKey="De Medeiros Ribeiro A" first="Ana Cristina" last="De Medeiros Ribeiro">Ana Cristina De Medeiros Ribeiro</name><name sortKey="De Medeiros Ribeiro, Ana Cristina" sort="De Medeiros Ribeiro, Ana Cristina" uniqKey="De Medeiros Ribeiro A" first="Ana Cristina" last="De Medeiros Ribeiro">Ana Cristina De Medeiros Ribeiro</name><name sortKey="Levy, Mauricio" sort="Levy, Mauricio" uniqKey="Levy M" first="Mauricio" last="Levy">Mauricio Levy</name><name sortKey="Pereira, Rosa Maria Rodrigues" sort="Pereira, Rosa Maria Rodrigues" uniqKey="Pereira R" first="Rosa Maria Rodrigues" last="Pereira">Rosa Maria Rodrigues Pereira</name><name sortKey="Saad, Carla Goncalves Schain" sort="Saad, Carla Goncalves Schain" uniqKey="Saad C" first="Carla Gonçalves Schain" last="Saad">Carla Gonçalves Schain Saad</name><name sortKey="Saad, Carla Goncalves Schain" sort="Saad, Carla Goncalves Schain" uniqKey="Saad C" first="Carla Gonçalves Schain" last="Saad">Carla Gonçalves Schain Saad</name><name sortKey="Silva, Clovis A" sort="Silva, Clovis A" uniqKey="Silva C" first="Clovis A." last="Silva">Clovis A. Silva</name><name sortKey="Silva, Clovis A" sort="Silva, Clovis A" uniqKey="Silva C" first="Clovis A." last="Silva">Clovis A. Silva</name><name sortKey="Silva, Clovis A" sort="Silva, Clovis A" uniqKey="Silva C" first="Clovis A." last="Silva">Clovis A. Silva</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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